The effect of leadless pacing on LV and RV systolic function is not inferior to conventional RV pacing

Abstract Introduction Leadless right ventricular (RV) pacing has been recently proposed as alternative to conventional pacemakers (PM's). While RV with a PM is known cause deterioration of left (LV) and systolic function over time, the effects leadless PM's are currently under-explored. In this prospective randomized study, we hypothesized that effect time on both LV not inferior pacing. Methods Fifty-one age-matched patients guideline indication for were prospectively recruited undergo implantation either (i) PM, or (ii) PM. Patients underwent echocardiography prior (BL), at 6 12 months (M6 & M12) after implantation. All imaging was performed during active Analysis included ejection fraction (LVEF), global longitudinal strain (GLS), free wall (FW) strain. Results Twenty-seven implanted while twenty-four received Median age 82 (80–87) years. At BL, average LVEF GLS normal similar in groups. M12, (−12%) (−5%) decreased significantly study groups (ANOVA p<0.0001, see Figure 1). FW only (−4%; ANOVA p=0.031, 1; post-hoc test BL vs. M12: p=0.029). None tested variables, none points, showed significant difference between (all p>0.05). percentage 68.2% (at all time-points Conclusions Both demonstrate decrease function, groups, most prominent treated PM's. Our data suggest regard cardiac function. Funding Acknowledgement Type funding sources: Foundation. Main source(s): Research Foundation Flanders (FWO) post-doc grant